Comparisons with more recent data reveal many of these insights to be unattainable without archival, full-genome sequences.
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A patent, ‘Methods and systems for RNA or DNA detection and sequencing’ (US patent application 62/325,320), has been filed with the United States Patent and Trademark Office.
The findings and conclusions in this report are those of the author(s) and do not necessarily represent the official position of the Centers for Disease Control and Prevention.
Bayesian phylogenetic analyses estimate the jump to the US at around 1970 and place the ancestral US virus in New York City with 0.99 posterior probability support, strongly suggesting this was the crucial hub of early US HIV/AIDS diversification.
Logistic growth coalescent models reveal epidemic doubling times of 0.86 and 1.12 years for the US and Caribbean, respectively, suggesting rapid early expansion in each location.
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